ORGN 74 |
| The synthesis of 2-deoxy-beta-glycosides has proven to be a challenging task due to the missing control element at the 2-position. An asymmetric synthesis of 2-deoxy-beta-monosaccharide has been developed and it is compatible to syntheses of the natural oligosaccharides digoxose and digitoxin. Our approach relies on the iterative application of a palladium catalyzed glycosylation, reductive 1,3-transpostion and diastereoselective dihydroxylations.
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Asymmetric Reactions and Syntheses
1:00 PM-5:00 PM, Sunday, 10 September 2006 Moscone Center -- Room 131, Oral
Division of Organic Chemistry |
