Novel selective syntheses of indoles or quinolines from 2-nitrostyrenes

ORGN 562

Serge R Banini, sbanini@mix.wvu.edu and Bjorn GC. Soderberg, bjorn.soderberg@mail.wvu.edu. Department of Chemistry, West Virginia University, Morgantown, West Virginia, WV 26506-6045
The indoles and quinolines skeletons are found in a large variety of naturally occurring and synthetic heterocyclic compounds. We have recently developed a methodology accessing both indoles and quinolines from a common immediate precursor. This novel methodology allows for the exclusive formation of either ring system from readily available 2-nitrostyrene in good yields (80-90%) using a palladium-catalyzed reductive heteroannulation as the key step

 

New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006