ORGN 69 |
| Mannopeptimicins are cyclic hexa-peptides with a disaccharide side chain, which possess potent antibacterial activity against gram-positive bacteria with good activity against multi drug-resistant (MDR) bacteria. The disaccharide fragment of Mannopeptimycin is known to be the key to activity which has been synthesized in 7 steps from tyrosine in 37% overall yield using our de novo approach to carbohydrate synthesis. Herein, we will describe our recent efforts toward the total synthesis of Mannopeptimycin analogues from corresponding amino acids.
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Asymmetric Reactions and Syntheses
1:00 PM-5:00 PM, Sunday, 10 September 2006 Moscone Center -- Room 131, Oral
Division of Organic Chemistry |
