ORGN 717 |
| Kidamycin 1 is a representative member of the pluramycin family of anticancer antibiotic natural products. We are studying the total synthesis of kidamycin by a strategy of direct sequential glycosylation of angolosamine glycosyl donor 3 and vancosamine glycosyl donor 4 to the core aglycone synthon 2, which we reported in 2005. Both glycosyl donors 3 and 4 have been synthesized by applying our tungsten catalyzed cycloisomerization of alkynols into glycals. The introduction of angolosamine glycosyl donor 3 to 2 has been achieved, and the total synthesis of kidamycin is in progress.
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
