ORGN 921 |
| Natural products are often complex molecules with multiple chiral centers, designed to interact with biological systems. Utilization of natural products as a source of structural or functional templates for design and synthesis of a wide variety of novel molecules has been an important aspect of new drug design. Isolation of a number of biologically active di- and triterpenes such as abietanes, drimanes, compounds of mixed biosynthetic pathways, labdane diterpenes, sesterterpenes, quassinoids, and podolactones has greatly stimulated several synthetic and semi-synthetic efforts for the preparation of these compounds and their analogues. Several groups have utilized the naturally occurring labdane diterpenes viz., manool, sclareol, sclareolide and communic acids as starting materials for this purpose. Most of the methods involved side chain degradations of labdanes. In our efforts to synthesize a number of structurally diverse bioactive diterpenes, we developed several efficient semi- synthetic routes for their preparation using Andrographolide, the major constituent of the Indian medicinal plant Andrographis paniculata (Acanthaceae) as a starting material. Synthetic strategies adopted will be presented.
|
|
Total Synthesis of Complex Molecules
1:00 PM-5:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 134, Oral
Division of Organic Chemistry |
