ORGN 73 |
| Using the asymmetric hydration sequence developed in our labs two important natural products are now being targeted for synthesis, RK-397 and virginiamycin. Combined with the Leighton allylation procedure, our asymmetric hydration allows us to set nearly all the stereocenters in RK-397 and virginiamycin. The starting materials for this efficient reaction sequence are simple, achiral conjugated dienoates, which are converted rapidly into complex enantio-enriched building blocks for natural products like RK-397 and virginiamycin.
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Asymmetric Reactions and Syntheses
1:00 PM-5:00 PM, Sunday, 10 September 2006 Moscone Center -- Room 131, Oral
Division of Organic Chemistry |
