ORGN 538 |
| A novel, efficient and general synthesis of N-aryl-1,4-dihydropyridines via a trifluoacetic acid catalyzed cascade reaction between aromatic amines and 3-(2-formylphenoxy)-prop-2-enoates has been successfully developed. The reaction was performed under mild conditions and gave excellent yields. It is noteworthy that the products could be easily transformed into pharmaceutically interesting 1,4-dihydropyridines libraries. Furthermore it was also found that the enoate form products exhibit good fluorescence properties and three representative products were screened for their optical properties. |
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |