Towards the synthesis of axivalin via a manganese(III)-mediated radical cyclization

ORGN 180

Andrew Tang, at367@cam.ac.uk1, David G. Hulcoop, jwb1004@hermes.cam.ac.uk1, JJ. Kulagowski2, and Jonathan W. Burton, jonathan.burton@chem.ox.ac.uk1. (1) Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom, (2) Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2 QR, UK, United Kingdom
Work within our group has shown that manganese(III) acetate, in conjunction with highly dissociated copper salts, can mediate intramolecular radical cyclisations amenable to the construction of polycyclic systems. This methodology is currently being applied to the synthesis of the carbon skeleton of axivalin, a sesquiterpene natural product.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006