Exploiting the whole cell-mediated biotransformation of arenes as a source of enantiomerically pure building blocks for the chemical synthesis of biologically important natural products

ORGN 719

Jonathan S. Foot, jfoot@rsc.anu.edu.au and Martin G. Banwell. Research School of Chemistry, The Australian National University, Canberra, Australia
Various micro-organisms that over-express dioxygenase-type enzymes can be used in the whole-cell biotransformation of a wide range of arenes, particularly halogenated aromatics, into the corresponding cis-1,2-dihydrocatechol. The products of such processes are generally obtained in enantiomerically pure form and contain a diverse array of strongly differentiated functionality. As such these metabolites represent extraordinarily valuable starting materials for the chemical synthesis of a wide-range of biologically active natural products and related species. This presentation will detail the use of these building blocks in the total synthesis of certain natural products of current interest.

 

Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006