Study of the binding properties of new water-soluble receptors

ORGN 768

Hillary J Van Anda, Richard J Hooley, rjhooley@scripps.edu, and Julius Rebek Jr., jrebek@scripps.edu. The Skaggs Institute for Chemical Biology and the Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037
Hydrophobic interactions can play a large role in the binding of small organic molecules in biological systems. We present a water-soluble synthetic receptor with four benzoate groups attached to the open end. These groups control the rate of guest exchange by acting as revolving doors. Binding properties were studied using 1-D and 2-D NMR methods. The nature of the receptor's inner surface was investigated via UV/Vis and time-resolved fluorescence spectroscopy.