ORGN 699 |
| A new efficient method for the synthesis of scyphostatin and its analogs is presented. Starting from 2,4-dihydroxy benzylaldehyde, an advanced tyrosine analog enantioselectively prepared in 6 steps. Distereoselective cyclization of the tyrosine analog with PIFA followed by selective epoxidization give the core of scyphostatin. A sorbic acid derivative is prepared.
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Total Synthesis of Complex Molecules
1:00 PM-5:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 132, Oral
Division of Organic Chemistry |
