ORGN 764 |
| A series of rigid small-molecules based on phenylacetylene motifs have been synthesized, and subsequently functionalized with oligonucleotide strands to form small-molecule DNA hybrids (SMDH's)(Figure). As models for elucidating the origin of sharp-melting in organic polymer materials, these SMDH's have been designed such that the number and orientation of oligonucleotides on an individual unit can be controlled and tuned. Aggregates are formed when an SMDH is exposed to its complementarily functionalized SMDH or a polymer-DNA hybrid possessing complementary DNA strands. The effect of the number of strands and their orientation on the thermal and recognition properties of these aggregates will be compared to that of free-DNA duplexes.
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
