Organometallic chemistry in living cells

ORGN 474

Craig Streu, streu@sas.upenn.edu and Eric Meggers, meggers@sas.upenn.edu. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Box 138, Philadelphia, PA 19104-6323
Transition metal complexes are highly tunable species capable of catalyzing a wide variety of transformations that could prove useful for applications within the living cell. Unfortunately, much of the chemistry of these compounds is limited to anaerobic, highly concentrated, and/or scavenger-free systems. Such limitations have made it difficult to harness the catalytic activity of these compounds in biological systems. This work outlines the discovery, optimization, and application of a ruthenium-based carbamate cleavage in a living cell.

 

New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006