ORGN 948 |
| Diversity Oriented Synthesis (DOS) constitutes a powerful new strategy for the synthesis of small molecules that are predicted to have important biological activity. Our DOS approach is based on the use of a pivotal substrate that when subjected to different reaction conditions, affords new, skeletally unique products. In this presentation, we will discuss the synthesis of novel conjugated triene ring systems. Using [Rh(CO)2Cl)2 as the catalyst under nitrogen atmosphere [5, 5], [5, 6] and [5, 7] bicyclic skeletons are afforded in good yields. The scope and limitations of this triene forming method to prepare enamides will be discussed along with the potential application of this strategy to the total synthesis of natural products.
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New Reactions and Methodology
1:00 PM-5:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |
