ORGN 32 |
| The 1,8-naphthalimide chromophore possesses interesting photophysical properties, which are very sensitive to the surrounding environment. They also possess planar geometry, which is ideal for interaction with DNA. As such they show potential as probes for DNA. Polypyridyl ruthenium complexes also show interesting changes in their photophysical properties upon interaction with DNA, and certain complexes have the ability to cleave DNA upon activation by visible light. These complexes possess defined octahedral geometry, allow access to different chiral forms, and are highly stable. They may contain ligands with extended planarity, which along with their positive centre leads to very strong binding to DNA. This work concerns the development of Ru(bpy)3-Naphthalimide based DNA probes, which exploit the photophysical and DNA binding properties of both components. A number of water soluble bichromophore target complexes were synthesised and their interaction with nucleic acids investigated using various spectroscopic techniques. |
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Physical Organic Chemistry: Calculations, Mechanisms, Photochemistry, and High-Energy Species
8:00 AM-11:40 AM, Sunday, 10 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |