One-pot multi-catalyst reactions enabled by encapsulated catalysts

ORGN 15

D. Tyler McQuade, dtm25@cornell.edu, Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratories, Ithaca, NY 14853
Thanks to the intense efforts of the organic chemistry community, most conceivable molecules can be synthesized, but wasteful and expensive routes are often required. Thus, targets of high practical value, e.g., pharmaceutical agents, can be challenging to produce even if they are only moderately complex. We believe that synthesis can be made much more efficient by designing processes in which multiple catalysts operate sequentially in "one pot." Ultimately, this approach should reduce the cost and waste associated with pharmaceutical synthesis. We will present materials, methods, and synthetic routes supporting the stated goals. In particular, we will focus on multi-catalysts systems where two catalysts in one system yield a different product than if the two catalysts were used alone.