ORGN 183 |
| η3-Pyranylmolybdenum π-complexes as organometallic chirons have been demonstrated as excellent scaffolds in the enantiocontrolled synthesis of highly functionalized heterocycles. Recently, a novel methodology has been developed in the stereoselective synthesis of 2,2,6-trisubstituted tetrahydropyans. Through sequential Mukaiyama-Aldol reaction, semipinacol rearrangement, “1,5-Michael-Type” reaction and demetallation, the 5-oxo-TpMo(CO)2(pyranyl) complex can be transformed to various 2,2,6-trisubstituted tetrahydropyrans with complete control of stereochemistry. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |