Highly efficient synthesis of enantiomerically enriched 2-aziridinemethanols by lipase desymmetrization

ORGN 158

Jun Young Choi, choijy@pharmacy.purdue.edu and Richard F. Borch. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 201 South University St., West Lafayette, IN 47907
Both enantiomers of protected and unprotected 2-aziridinemethanols are efficiently and stereoselectively synthesized through the combination of enzymatic and synthetic methods. PPL was employed for lipase desymmetrization of N-protected serinol.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006