ORGN 93 |
| Synthetic ion channels that open and close in response to specific signals are of interest for the development of new materials such as biosensors and therapeutics. Our goal is to achieve redox gated transmembrane ion transport through monomolecular channels. The target channel includes a pore-forming cyclic peptide with membrane-spanning chains attached to one face. Two amino acids with thiol-terminated side chains comprise the redox-active gate. Initial efforts toward the synthesis of the target channel as well as ion transport studies with a non-gated analog will be presented. |
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Materials, Devices, and Switches
1:00 PM-5:00 PM, Sunday, 10 September 2006 Moscone Center -- Room 132, Oral
Division of Organic Chemistry |