ORGN 70 |
| Due to its structural complexity and potent cytotoxicity against a wide range of cancer cells pectenotoxin has been the focus of many synthetic groups since its initial discovery in 1985. Spirodiepoxides are an under-utilized functional group that our group has recently applied to target-oriented synthesis in accessing alpha-hydroxy ketones. This talk will discuss intramolecular reactions designed to exploit spirodiepoxides in the stereoselective construction of the A-B spiroketal ring system of pectenotoxin.
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Asymmetric Reactions and Syntheses
1:00 PM-5:00 PM, Sunday, 10 September 2006 Moscone Center -- Room 131, Oral
Division of Organic Chemistry |
