ORGN 116 |
| Further improvement of a practical, organocatalytic protocol for the enantioselective reduction of prochiral N-aryl ketimines has been achieved by rational optimization of the catalyst structure. The method relies on the use of trichlorosilane as the stoichiometric reducing reagent activated by catalytic quantities of valine-derived N-methyl formamides. This metal-free protocol approaches the efficiency of the traditional, metal-catalyzed methodology, furnishing the corresponding amines in up to 96% ee at just 1 mol % catalyst loading. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |