ROBIA: Computational analysis of synthetic processes

ORGN 626

Jonathan M Goodman, J.M.Goodman@ch.cam.ac.uk and Ingrid M Socorro, ims28@cam.ac.uk. Unilever Centre for Molecular Science Informatics, Cambridge University, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
The ROBIA (Reaction Outcome By Informatics Analysis) program analyses organic transformations using conformation analysis and molecular modeling to generate and to evaluate competing reaction pathways. This can be used both to assess the likely stability of candidate structures and also to examine synthetic pathways towards these molecules. The strategy is based on trusting molecular modeling more than the synthetic literature, so that the results can be used as a test for reported reactions.