Total synthesis of the macrolide core of (-) Borrelidin

ORGN 647

Vamsee K. Chintakunta, VAMSEEKRISHNA1@REDIFFMAIL.COM1, Santanu Maitra, santanumaitra@drreddys.com1, K Mukkanti, kmukkanti@rediffmail.com2, and Javed Iqbal, javediqbaldrf@hotmail.com1. (1) Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories, Ltd, Bollaram Road, Miyapur, Hyderabad, 500049, India, (2) Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad, 500072, India
Borrelidin was first isolated from Streptomyces rochei in 1949 by Jampolsky and Goldberg. Borrelidin exhibits a broad antiviral, antibacterial, antiangiogenic and antimitotic properties. The combination of an unusual chemical structure and a diverse biological profile has led to several synthetic routes for the synthesis of this macrolide. As part of our endeavor to synthesize this complex macrolide, we present here the total synthesis of the macrocyclic core of Borrelidin.

 

Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 132, Oral

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006