ORGN 789 |
| Pheochromocytomas are a cancer of the adrenal gland. Pheochromoocytomas produce a variety of catecholamines, including norepinephrine. The result is high blood pressure which is caused by the release of catecholamines into the bloodstream (i.e. elevated concentration of plasma or urinary catecholamines). Detecting this cancer by measurement of catecholamine concentrations in serum can be challenging for the clinician. We have designed and synthesized a coumarin based sensor that reversibly covalently binds with both the amine and catechol moieties of catecholamines via the formation of an iminium ion and boronate ester respectively. With the fluorescence response of the binding process we can then accurately determine the concentration of catecholamines, thereby facilitating diagnosis.
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
