ORGN 575 |
| Dihydropyridazinone compounds have been shown to be potential isozyme selective inhibitors of phosphodiesterase (PDE). This selectivity offers opportunities for the development of treatments for congestive heart failure, pulmonary, and inflammatory diseases as well as the studies of the physiological function of PDE7. The presence of chirality in the dihydropyridazinone has been shown to impact the isozyme selectivity of this class of inhibitor. To access a library of chiral cycloalkane condensed 4,5-dihydropyridazinones we have undertaken a synthesis utilizing Meyers' bicyclic lactams. In this presentation we will show our progress to date in the stereoselective formation of chiral cycloalkane condensed 4,5-dihydropyridazinones.
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
