Synthesis and anti-HIV-1 activity of novel fluoroalkyl end-capped cooligomers/silica nanoparticles

COLL 220

Hideo Sawada, hideosaw@cc.hirosaki-u.ac.jp1, Tamikazu Narumi, hideosaw@cc.hirosaki-u.ac.jp1, Makiko Kiyohara2, and Masanori Baba2. (1) Department of Frontier Materials Chemistry, Hirosaki University, Bunkyo-cho, Hirosaki 0361-8561, 036-8561, Japan, (2) Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima-city, 890-8544, Japan
Fluoroalkyl end-capped acrylic acid and sulfonic acid cooligomers reacted with tetraethoxysilane (TEOS) and silica/nanoparticles under alkaline conditions to afford the corresponding fluorinated cooligomers/silica nanoparticles (mean diameters: 32 ~ 180 nm) with a good dispersibility and stability in aqueous and organic media. Interestingly, fluorinated nanoparticles containing carboxy groups were found to exhibit a potent and selective anti-HIV-1 activity in vitro. In contrast, fluorinated cooligomers containing sulfo groups were shown to have a potent and selective anti-SIV activity in vitro.
 

Advances in Nanomedicine
1:30 PM-5:20 PM, Monday, 11 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral

Division of Colloid & Surface Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006