ORGN 775 |
| This poster describes new classes of nonpeptidic foldamers that display protein-like functionality. These foldamers were prepared by swapping amide bonds between amino acids with heteroaromatic rings. Our first design involved replacement of the amide bonds with 1,2,3-triazole linkages using the well-studied copper (I) catalyzed Huisgen cycloaddition reaction between amino acid azides and amino acid alkynes. 2D NMR studies suggest that these foldamers adopt zigzag conformations. We are also developing other classes of nonpeptidic foldamers designed to adopt helical conformations. The synthesis and characterization of these compounds along with their potential to regulate protein–protein interactions will be discussed.
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
