Diazonamide A (1) a natural product isolated from Diazona angulata shows potent in vitro cytotoxic activity against HCT-116 human colon carcinoma and B-16 murine melanoma cancer cell (IC₅₀ values of less than 15 ng/mL).   Originally isolated and assigned by Fenical and coworkers, was later corrected and reassigned by Harran and coworkers.  Our synthetic route focus on the initial high yielding stereospecific Pb(IV)-aryllation forming the C10 quartenary center.  Further progress of the construction of the left hand macrocycle and formation of the 16-18 biaryl coupling will also be presented.