Electrophilic cyclization of 3-alkynyl esters

ORGN 869

Ziwei W Just and Richard C. Larock, larock@iastate.edu. Department of Chemistry, Iowa State University, Gilman Hall, Ames, IA 50011
The electrophilic cyclization of 3-alkynyl esters and acids leads to the highly substituted 2-furanones in excellent yields under very mild reaction conditions. Iodine, ICl, PhSeCl have proven to be successful electrophiles in this process.