Palladium-catalyzed asymmetric Michael reactions

ORGN 197

Warda A Muse, w.muse@imperial.ac.uk1, Denis Billen, Denis.Billen@pfizer.com2, and King Kuok Mimi Hii, mimi.hii@imperial.ac.uk1. (1) Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, United Kingdom, (2) Veterinary Medicine, Pfizer Limited, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom
Catalytic enantioselective Michael addition reaction has become a popular subject area in recent years due to their high synthetic utility; these reactions can generate stereogenic quaternary carbon centres, and provide routes to optically active chiral building blocks for the synthesis of chiral natural products and drugs. In this presentation, we will describe results obtained from parallel ligand screening of chiral palladium catalysts in selected asymmetric Michael reactions, and their applications in organic synthesis.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006