Synthesis and biological activity of diazofluorenes and diazobenzofluorenes

ORGN 864

Christian Melander, T. Eric Ballard, and Wei Zeng. Department of Chemistry, North Carolina State University, Raleigh, NC 27695
The synthesis and biological activity of diazofluorene and diazobenzofluorene derivatives will be presented. Simplified derivatives that mimic the DNA cleaving activity of kinamycin D have been identified. Their ability to inhibit the proliferation of cancer cells will also be discussed.