ORGN 936 |
| The ability to target BIV TAR RNA with cysteine-constrained peptides identified through phage selection will be presented. By screening a seven random amino acid library, flanked by two invariant cysteine residues, we are able to identify candidate cyclic peptides that bound to a biotinylated BIV TAR RNA sequence. We also demonstrate by including a negative selection round, where phage that non-specifically bind to random RNA are removed from further rounds of selection, the phage pool can be narrowed to bias the identification of sequence-specific binders. |
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Proteins, Peptides, Amino Acids, and Enzyme Inhibitors
1:00 PM-5:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 131, Oral
Division of Organic Chemistry |