ORGN 110 |
| Ethyl-3-cyano-5 methyl-hex-3-enoate, a key intermediate for the asymmetric hydrogenation route to pregabalin is obtained by a three-step process using cheap starting materials. Step 1 is a Baylis-Hillman reaction, step 2 is an acylation, and step 3 is a palladium-catalyzed carbonylation. Various issues were encountered at all steps during scale-up of process from laboratory to pilot plant. The identification of these issues, the challenges to solve the problems will be presented.
|
|
Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
