ORGN 139 |
| Organocatalytic asymmetric domino reactions are presented. Simple chiral pyrrolidine derivatives catalyze the asymmetric domino and conjugate addition to α,β-unsaturated aldehydes with high enantioselectivity. The concept involves, first, an organocatalyzed asymmetric nucleophilic addition to the β-carbon in the iminium ion intermediate, followed by an electrophilic attack on the α-carbon in the enamine intermediate. The corresponding products are isolated in high yields and ee's. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |