Organocatalytic enantioselective Michael addition of thioacetic to nitroolefins and enones

ORGN 147

Hao Li, haoli@unm.edu, Jian Wang, Liansuo Zu, and Wei Wang, wwang@unm.edu. Department of Chemistry, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001
An organocatalyzed enantioselective Michael addition reactions of thioacetic acid with a range of trans-beta-nitrostyrenes and enones has been developed. The processes, promoted by the chiral amine thiourea organocatalyst, take place in excellent yields with up to 70% ee.
 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006