ORGN 146 |
| A method for direct, stereoselective preparation of (E) alpha, beta-unsaturated ketones from ketones and aldehydes, promoted by a novel pyrrolidine imide organocatalyst, has been developed in moderate to high yields. Unlike the Claisen-Schmidt condensation and Lewis-acid catalyzed tandem aldol-dehydration processes, this method provides mild reaction conditions to access alpha, beta-unsaturated ketones from simple, unmodified ketones. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |