ORGN 65 |
| Synthetic organic chemistry continues to play an important role in many biological fields. We have recently accomplished a very concise total synthesis of antitumor natural product FR901464 through the development of new synthetic methods. This natural product regulates the transcription of both oncogene and tumor suppressor genes. To analyze in vivo transcriptional activities, fluorescent imaging of RNA is crucial, but such technology is not readily available. We have devised a new paradigm for developing cell-permeable small molecules that fluoresce when bound to specific RNA. In this presentation, we will discuss our ongoing synthetic and biological studies of FR901464 and RNA imaging.
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Young Investigators Symposium
1:00 PM-5:00 PM, Sunday, 10 September 2006 Moscone Center -- Room 135, Oral
Division of Organic Chemistry |
