ORGN 289 |
| Dictyostatin is a potent anti-cancer agent that acts by stabilizing microtubules. An evolving total synthesis of members of the dictane family that uses both traditional and fluorous methods will be described. The synthesis has recently been used to make about two dozen isomers and analogs of dictyostatin. Results of biological assays of these analogs, some of which are highly potent anti-cancer agents, provide the first outline of the structure/activity relationship (SAR) in this important family of natural products.
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Tetrahedron Prize for Creativity in Organic Chemistry
1:00 PM-5:02 PM, Monday, 11 September 2006 Moscone Center -- Room 134, Oral
Division of Organic Chemistry |
