ORGN 500 |
| The conjugate addition of aryl boronic acids to unsaturated carbonyl compounds remains one of the most versatile methods for the formation of carbon-carbon bonds. Herein we report the development of a mild set of conditions using a new rhodium catalyst in aqueous media, which is effective for a wide range of sterically hindered substrates. These conditions utilize low levels of catalyst loading (0.5 mol% to 1.0 mol %) and boronic acid (1.2 to 2 equivalents relative to olefin) to produce the desired 1, 4 conjugate addition products. Studies to elucidate the scope and versatility of this system will be described.
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
