ORGN 932 |
Due to their absorption at long wavelengths, isoporphyrins (1) are potential candidates as photosensitizers for photodynamic therapy of tumors. They are also of both chemical and biological interest due to their unique redox behavior among porphyrin derivatives. Isoporphyrins are known to be very unstable with respect to transformation back to the fully conjugated porphyrin chromophore (2) except when a meso-carbon is germinally substituted (3) and for this reason a detailed study of this macrocycle has previously been prevented. However, a synthetic route by way of open-chain tetrapyrrole precursors has been developed to afford the target compound as its metal complex form and other porphyrin derivatives. Stability studies have also been done to yield and characterize novel stable metal-free isoporphyrins. These compounds have also been studied for their biological properties applicable to photodynamic therapy, a binary modality for cancer treatment. The total synthesis, stability studies and biological applications will be presented.
<>
|
|
Heterocycles and Aromatics
1:00 PM-4:40 PM, Thursday, 14 September 2006 Moscone Center -- Room 135, Oral
Division of Organic Chemistry |
