Efficient and highly enantioselective carbonyl reduction with borane catalyzed by chiral spiriborate esters

ORGN 106

Viatcheslav Stepanenko, the3spiritslava@hotmail.com, Margarita Ortiz-Marciales, Wildeliz Correa, Melvin De Jesús, Sandraliz Espinosa, and Lymaris Ortiz. Department of Chemistry, University of Puerto Rico, UPRH, CUH Station, Humacao, PR 00791
Novel spiroborate esters derived from nonracemic 1,2-aminoalcohols have been examined as chiral catalysts in the borane reduction of aromatic ketones. The optically active alcohols were obtained in excellent chemical yields and enantioselectivities up to 99% ee.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006