ORGN 681 |
| The conjugate addition of aryl boronic acids to unsaturated carbonyl compounds is a versatile and mild approach to carbon-carbon bond formation. We report the application of a new rhodium quinone catalyst that provides a mild, highly effective and operationally facile procedure for conjugate addition of aryl boronic acids to conjugate acceptors. Our method is effective for a wide range of electron rich and deficient aryl boronic acids requiring low catalyst loading (0.5 mol%) and low boronic acid equivalency (1.2 equiv. relative to olefin) affording excellent yields (91-99%) of addition adducts.
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New Reactions and Methodology
1:00 PM-5:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |
