Conjugation of siloxane-containing compounds with amino acids, peptides, and sugars 

ORGN 941

Karen M Polizzi, K.M.Polizzi@exeter.ac.uk1, Jason P. Hallett, j.hallett@imperial.ac.uk2, Reagan R. Charney3, Megan Donaldson, mdonaldson@chbe.gatech.edu4, Pamela Pollet3, Kurt F. Brandstadt5, Thomas H. Lane5, Charles A. Eckert, cae@gatech.edu6, Charles L. Liotta3, and Andreas S. Bommarius, andreas.bommarius@che.gatech.edu7. (1) School of Biosciences, University of Exeter, Geoffrey Pope Builiding, Stocker Rd, Exeter, EX4 4QD, United Kingdom, (2) School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, NW, Atlanta, GA 30318, (3) School of Chemistry and Biochemistry and Specialty Separations Center, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332-0100, (4) Department of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, GA 30332, (5) Dow Corning Corporation, Midland, MI 48686, (6) School of Chemical and Biomolecular Engineering and Specialty Separations Center, Georgia Institute of Technology, 311 Ferst Drive, NW, Atlanta, GA 30332-0100, (7) Schools of Chemical Engineering and Chemistry/Biochemistry, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332-0363
Siloxane conjugates of biological building blocks such as amino acids and carbohydrates have unique antimicrobial and material properties.  However, the production of such molecules on a large scale is hindered by the fact that the siloxane molecules are generally hydrophobic, whereas the biomolecules are extremely hydrophilic.  Thus, the reaction rates hinge on the ability to bring both molecules in contact, preferably into a single phase.  We have used several techniques including phase-transfer catalysis medium engineering, and gas-expanded liquids to increase the mutual solubilities of these molecules, and thereby to increase productivities.
 

Proteins, Peptides, Amino Acids, and Enzyme Inhibitors
1:00 PM-5:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 131, Oral

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006