ORGN 295 |
| Enantioselective organocatalysis has emerged as a powerful and complementary synthetic paradigm to metal catalyzed transformations and has accelerated the development of new methods to make diverse chiral molecules. In particular the use of chiral amine catalysts has had a dramatic impact on this exciting field and has led to the discovery of a wide range of new asymmetric processes. We are interested in the generation of new catalyst induced reactivity in simple organic molecules in order to promote a range of chemical reactions. For example, using this strategy, a concept based on the catalytic generation of asymmetric ammonium ylides has been developed for cyclopropanation. We have also developed a catalytic [2,3]-Wittig rearrangement via enamines using simple pyrrolidine organic catalysts. This lecture will detail our work in Cambridge towards the development of new enantioselective organocatalytic reactions and their use in the chemical synthesis of architecturally complex molecules.
|
|
Organocatalysis
1:00 PM-5:05 PM, Monday, 11 September 2006 Moscone Center -- Room 135, Oral
Division of Organic Chemistry |
