Organocatalytic enantioselective synthesis of α-hydroxy phosphonates

ORGN 498

Sampak Samanta, sampak.samanta@utsa.edu and Cong-Gui Zhao. Department of Chemistry, University of Texas at San Antonio, 6900 N. Loop 1604 W, San Antonio, TX 78249
We have developed an organocatalytic highly enantioselective cross aldol reaction of á-ketophosphonates and ketones for the synthesis of optically active á-hydroxy phosphonates using L-proline or L-prolinamide as the catalyst. The regio-, diastereo-, and enantioselectivity of this novel cross aldol reactions will be discussed.