ORGN 743 |
| The application of an enantioselective Suzuki desymmetrisation as the key transformation in the total synthesis of naturally occurring alkaloids is described. The design of a suitable boronic substrate and its subsequent coupling with a range of functionalized meso-chimonanthines (I) to yield optically active hodgkinsine (II) is being investigated. As well as application to the desymmetrisation of meso compounds, this methodology is expected to be applicable to other achiral substrates such as calycanthine to furnish calycosidine (III).
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
