ORGN 419 |
| While strategies for the oxidative functionalization of saturated C-H bonds continue to evolve rapidly, a general, catalytic methodology for the selective hydroxylation of aliphatic C-H bonds remains elusive. Using a combination of experimental and theoretical techniques, we have designed, synthesized, and fully characterized a unique class of tricyclic oxaziridine-based oxidants. Unlike most known oxaziridines, these compounds proved capable of O-atom transfer to aliphatic olefins and C-H bonds under mild conditions. In the presence of a suitable co-catalyst and the benign terminal oxidant urea hydrogen peroxide (UHP), these processes are rendered catalytic. Our efforts to develop general oxidative methodology employing this catalytic system will be presented. |
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New Reactions and Methodology
1:00 PM-5:20 PM, Tuesday, 12 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |