ORGN 740 |
| Chartelline C is a member of a small group of highly halogenated indole–imidazole marine alkaloids. Its unique structure includes a 10-membered ring condensed with a unique spiro β-lactam, a 6-bromoindoline and a gem-dimethyl imidazole ring. The securine and securamine alkaloids are believed to be biogenetically related to the chartellines via oxidation pathways. It is anticipated that formation of the spiro β-lactam at a late stage could proceed from a suitable macrolactam via oxidative cyclization. Our work in this area will be presented.
|
|
Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
