ORGN 373 |
| The grinding of reactants has recently been demonstrated as a versatile method for the synthesis of co-crystals. In that context, the potential of the method has been further expanded by the introduction of solvent-drop grinding, i.e. a grinding process accompanied by the addition of small amounts of solvent. Whereas the use of grinding methods to construct binary cocrystals is well known, the method is also promising for the construction of three-component solids. In this contribution we demonstrate how such solids, in the form of inclusion complexes of a self-assembled two-component host, can be constructed via grinding methods. The complexes, involving a host based on caffeine and succinic acid, are obtained through the application of either neat or solvent-drop grinding. The host is held together primarily through supramolecular synthons based on either O-H...N or C-H...O interactions so as to provide a structure that incorporates guest molecules stacked into molecular columns.
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Molecular Recognition and Self-Assembly
8:00 AM-12:00 PM, Tuesday, 12 September 2006 Moscone Center -- Room 132, Oral
Division of Organic Chemistry |
