N-Heterocyclic carbene copper(I)-catalyzed [3+2]-cycloaddition of azides and mono- or disubstituted alkynes

ORGN 466

Silvia Díez-González, sdiezgon@uno.edu, Chemistry Department, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA 70148 and Steven P. Nolan, snolan@iciq.es, Nolan group, Institut of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona, Spain.
A versatile and highly efficient catalytic system for the Huisgen cycloaddition reaction has been developed. Previously isolated or in situ generated azides yielded 1,2,3-triazoles with differently substituted alkynes, even internal ones. The catalytic system fulfills the requirements of ‘Click Chemistry' with its mild and convenient conditions, notably reactions are carried out in water or without solvent and simple isolation is performed with no purification step.

 

Modern Acetylene Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006